It sounds like the step up to a joke, doesn't it? Ask three different people and you'll get three different answers. But this stuff really matters if you're trying to write one and don't know how to get the tone and balance right.
I made a short YouTube video about this if you want to have look. It's only a few minutes long:
In fact, worrying about the tone and the balance of comedy with the drama are a bit of a red herring. What you're really looking for is clarity. What is the show? Do you know what it is? I unpack all of this in a 40 minute seminar called 'So What Is a Comedy Drama?' which you can watch as many times as you like for free. Go here for access to it. I hope it helps.